Estimating linear mixed effects models with truncated normally distributed random effects

نویسندگان

چکیده

Linear Mixed Effects (LME) models have been widely applied in clustered data analysis many areas including marketing research, clinical trials, and biomedical studies. Inference can be conducted using maximum likelihood approach if assuming Normal distributions on the random effects. However, applications of economy, business medicine, it is often essential to impose constraints regression parameters after taking their real-world interpretations into account. Therefore, this paper we extend classical (unconstrained) LME allow for sign its overall coefficients. We propose assume a symmetric doubly truncated (SDTN) distribution effects instead unconstrained which found literature. With aforementioned change, difficulty has dramatically increased as exact dependent variable becomes analytically intractable. then develop likelihood-based approaches estimate unknown model utilizing approximation distribution. Simulation studies shown that proposed constrained not only improves results, but also achieves satisfactory performance fits compared existing model.

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ژورنال

عنوان ژورنال: Communications in Statistics - Simulation and Computation

سال: 2022

ISSN: ['0361-0918', '1532-4141']

DOI: https://doi.org/10.1080/03610918.2022.2066696